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A unique B-cell model system for transdifferentiation and human immune modulation
The cells, derived from a B-cell acute lymphoblastic leukemia cell line, can be easily converted into human macrophage-like cells with 100% efficiency in just few days, recapitulating human macrophage function and biology better and more conveniently than existing model systems. They can be used for basic research and drug development purposes in relation...
Published: 2/19/2019
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Inventor(s): Thomas Graf, Francesca Rapino
Keywords(s): Autoimmune Diseases, Cardiovascular Diseases, Cell-based Assay, Immune / Inflammatory Diseases, Immuno-oncology, Infectious Diseases, Metabolic Diseases, Neurodegenerative Diseases, Oncology
Category(s): Therapeutics (Biologics & Compounds), Research Tools (cell lines, mice, kits, ABs, ...), Drug Targets & Mechanisms
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Novel strategy to find and eliminate latent HIV
The technology maps insert-specific expression across thousands of integrated HIV proviruses in the whole human genome.The technology can be used to identify the best (mix of) latency-reversing agents that can reactivate all latent HIV viruses which escape from antiretroviral therapies, making them susceptible to destruction.Technology:After integration...
Published: 2/19/2019
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Inventor(s): Guillaume Filion, Heng_chang Chen
Keywords(s): Cell-based Assay, Gene Regulation, Infectious Diseases
Category(s): Therapeutics (Biologics & Compounds), Drug Targets & Mechanisms, Methodology
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Animal-free assessment of cell stemness
A method based on nucleosome detection by high resolution microscopy reliably assesses pluripotency much faster than the current gold standard without the use of animals.It can be used to identify the pluripotent potential of stem and iPS cells.Technology:Stem cell research has grown significantly over the last years and the assessment of stemness will...
Published: 11/12/2020
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Inventor(s): Maria Pia Cosma, Maria Aurelia Ricci
Keywords(s): Cell Therapy, Cell-based Assay, Stem Cells, Super-Resolution Nanoscopy, Tissue Engineering, Tissue Regeneration
Category(s): Methodology
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