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Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing.
Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been difficult in part because a simple method to simultaneously quantify their abundance and chemical modifications is lacking. Here we introduce Nano-tRNAseq, a nanopore-based approach to sequence native tRNA populations that provides quantitative estimates of both...
Published: 9/29/2023   |   Inventor(s): Eva Novoa, Morghan Lucas, Leszek Pryszcz, Rebeca Medina Azmecua
Keywords(s): Algorithms, Bioinformatics, Biomarkers, Diagnostics, Liquid Biopsy, Oncology
Category(s): Methodology, Software & Algorithms
ccSOL omics: large-scale prediction of protein solubility, aggregation and folding
The ccSOL webserver provides large-scale calculations for protein solubility using physical-chemical properties. In addition to the proteome wide identification of soluble fragments on a large scale, ccSOL omics also performs single-point mutations throughout the whole protein sequence to identify susceptible areas. Using information from coil/disorder...
Published: 3/19/2020   |   Inventor(s): Gian Gaetano Tartaglia, Federico Agostini, Davide Cirillo, Riccardo Delli Ponti, Petr Klus
Keywords(s): Algorithms, Bioinformatics, Protein Aggregation and Misfolding, Protein Solubility, Protein Structure & Design, Software
Category(s): Software & Algorithms
New, targeted lung cancer treatment with splicing-modifying antisense oligonucleotides
A lead splicing-modifying antisense oligonucleotide (AON) locally delivered to the lungs of different mice models of lung cancer effectively reduces tumor growth in vivo. The lead AON could be applicable to the targeted treatment of lung adenocarcinoma, lung squamous cell carcinoma, breast, liver, prostate, colon, cervix and other tumor types displaying...
Published: 1/28/2019   |   Inventor(s): Juan Valcarcel, Jordi Hernandez Ribera, Elias Bechara
Keywords(s): Oncology, RNA Modulation Technologies, Spliceosome / Splicing
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
ELM-seq: A novel reporter system to optimize gene expression in vivo in an unbiased and comprehensive manner
Expression level monitoring by DNA methylation and sequencing (ELM-seq) allows optimizing sequence determinants of gene expression and translation comprehensively and more reliably than classical methods.The method can be of special relevance for bioengineering and industrial biotechnology, for the biosynthesis of useful molecules such as drugs, enzymes,...
Published: 2/19/2019   |   Inventor(s): Eva Yus, Jae-Seong Yang, Luis Serrano
Keywords(s): Bioengineering, Bioinformatics, Biologics, Biomarkers, Biotechnology, Gene Regulation, Next Generation Sequencing, Protein Expression / Production, Protein Solubility, Vaccines
Category(s): Biotechnology, Methodology
Natural, plant-based volatile organic compounds to control Drosophila suzukii pest
Certain naturally occurring, plant-based substances display toxicological properties on different Drosophila fruit fly (D.) species, with D. suzukii being the most susceptible.They can be used to control D. suzukii, which is a major global pest species.Technology :The Drosophila (D.) suzukii is currently one of the most important pestiferous species,...
Published: 5/13/2021   |   Inventor(s): Elie Fink, Matthieu Louis
Keywords(s): Pest control
Category(s): Life Stock & Agriculture
A unique B-cell model system for transdifferentiation and human immune modulation
The cells, derived from a B-cell acute lymphoblastic leukemia cell line, can be easily converted into human macrophage-like cells with 100% efficiency in just few days, recapitulating human macrophage function and biology better and more conveniently than existing model systems. They can be used for basic research and drug development purposes in relation...
Published: 2/19/2019   |   Inventor(s): Thomas Graf, Francesca Rapino
Keywords(s): Autoimmune Diseases, Cardiovascular Diseases, Cell-based Assay, Immune / Inflammatory Diseases, Immuno-oncology, Infectious Diseases, Metabolic Diseases, Neurodegenerative Diseases, Oncology
Category(s): Therapeutics (Biologics & Compounds), Research Tools (cell lines, mice, kits, ABs, ...), Drug Targets & Mechanisms
Novel strategy to find and eliminate latent HIV
The technology maps insert-specific expression across thousands of integrated HIV proviruses in the whole human genome.The technology can be used to identify the best (mix of) latency-reversing agents that can reactivate all latent HIV viruses which escape from antiretroviral therapies, making them susceptible to destruction.Technology:After integration...
Published: 2/19/2019   |   Inventor(s): Guillaume Filion, Heng_chang Chen
Keywords(s): Cell-based Assay, Gene Regulation, Infectious Diseases
Category(s): Therapeutics (Biologics & Compounds), Drug Targets & Mechanisms, Methodology
Novel, long-term treatment of Huntington’s disease by gene therapy
Novel synthetic zinc finger proteins delivered to the brain through the use of viral vectors, efficiently and selectively repress the mutant huntingtin gene in a mouse model of Huntington’s disease long term after a single intervention, and successfully restore the motor coordination to levels comparable to those in healthy controls in an acute...
Published: 2/19/2019   |   Inventor(s): Mark Isalan
Keywords(s): Biotechnology, Gene Therapy, Genetic Diseases, Neurodegenerative Diseases, Neuromuscular & Movement Disorders, Neuroscience, Rare / Orphan Diseases
Category(s): Biotechnology, General Biology & Chemistry, Therapeutics (Biologics & Compounds)
FoldX Suite - Protein Design Software
The FoldX Suite builds on the strong fundament of advanced protein design features, already implemented in the successful FoldX, and exploits the power of fragment libraries, by integrating in silico digested backbone protein fragments of different lengths. Such fragment-based strategy allows for new powerful capabilities: loop reconstruction, implemented...
Published: 5/15/2018   |   Inventor(s): Luis Serrano, Javier Delgado, François Stricher, Erik Verschueren, Peter Vanhee
Keywords(s): Algorithms, Bioinformatics, Protein Structure & Design, Software
Category(s): Software & Algorithms
catRAPID: large-scale sequence-based prediction of protein–RNA interactions
catRAPID estimates the binding propensity of protein-RNA pairs by using sequence information only. The algorithm can be used to predict protein associations with coding and non-coding transcripts. Predictions have proved very accurate (> 0.8) when validated by traditional Immunoprecipitation methods, like RIP and CLIP.Applications and Services:Identifies...
Published: 5/25/2020   |   Inventor(s): Gian Gaetano Tartaglia, Federico Agostini, Davide Cirillo, Petr Klus
Keywords(s): Algorithms, Bioinformatics, Biomarkers, Genomics, Protein Structure & Design, Software
Category(s): Software & Algorithms
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