ELM-seq: A novel reporter system to optimize gene expression in vivo in an unbiased and comprehensive manner
Expression level monitoring by DNA methylation and sequencing (ELM-seq) allows optimizing sequence determinants of gene expression and translation comprehensively and more reliably than classical methods.The method can be of special relevance for bioengineering and industrial biotechnology, for the biosynthesis of useful molecules such as drugs, enzymes,...
Inventor(s): Eva Yus, Jae-Seong Yang, Luis Serrano
Keywords(s): Bioengineering, Bioinformatics, Biologics, Biomarkers, Biotechnology, Gene Regulation, Next Generation Sequencing, Protein Expression / Production, Protein Solubility, Vaccines
Category(s): Biotechnology, Methodology
FoldX Suite - Protein Design Software
The FoldX Suite builds on the strong fundament of advanced protein design features, already implemented in the successful FoldX, and exploits the power of fragment libraries, by integrating in silico digested backbone protein fragments of different lengths. Such fragment-based strategy allows for new powerful capabilities: loop reconstruction, implemented...
Inventor(s): Luis Serrano, Javier Delgado, François Stricher, Erik Verschueren, Peter Vanhee
Keywords(s): Algorithms, Bioinformatics, Protein Structure & Design, Software
Category(s): Software & Algorithms
Novel peptide sequences for efficient protein secretion in bacteria
The peptides of the invention drive the optimal secretion of fused polypeptides out of Mycoplasma cells.They have multiple potential applications, in particular in the area of synthetic biology and next-generation bacterial-based therapies and vaccination.Technology:Synthetic biology enables researchers to engineer biological systems for a myriad of...
Inventor(s): Luis Serrano, Maria Lluch, Bernhard Paetzold
Keywords(s): Bioengineering, Synthetic Biology
Category(s): Therapeutics (Biologics & Compounds), Biotechnology, Life Stock & Agriculture, Research Tools (cell lines, mice, kits, ABs, ...), Vaccines