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New, targeted lung cancer treatment with splicing-modifying antisense oligonucleotides
A lead splicing-modifying antisense oligonucleotide (AON) locally delivered to the lungs of different mice models of lung cancer effectively reduces tumor growth in vivo. The lead AON could be applicable to the targeted treatment of lung adenocarcinoma, lung squamous cell carcinoma, breast, liver, prostate, colon, cervix and other tumor types displaying...
Published: 1/28/2019
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Inventor(s): Juan Valcarcel, Jordi Hernandez Ribera, Elias Bechara
Keywords(s): Oncology, RNA Modulation Technologies, Spliceosome / Splicing
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
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ELM-seq: A novel reporter system to optimize gene expression in vivo in an unbiased and comprehensive manner
Expression level monitoring by DNA methylation and sequencing (ELM-seq) allows optimizing sequence determinants of gene expression and translation comprehensively and more reliably than classical methods.The method can be of special relevance for bioengineering and industrial biotechnology, for the biosynthesis of useful molecules such as drugs, enzymes,...
Published: 2/19/2019
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Inventor(s): Eva Yus, Jae-Seong Yang, Luis Serrano
Keywords(s): Bioengineering, Bioinformatics, Biologics, Biomarkers, Biotechnology, Gene Regulation, Next Generation Sequencing, Protein Expression / Production, Protein Solubility, Vaccines
Category(s): Biotechnology, Methodology
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Novel, long-term treatment of Huntington’s disease by gene therapy
Novel synthetic zinc finger proteins delivered to the brain through the use of viral vectors, efficiently and selectively repress the mutant huntingtin gene in a mouse model of Huntington’s disease long term after a single intervention, and successfully restore the motor coordination to levels comparable to those in healthy controls in an acute...
Published: 2/19/2019
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Inventor(s): Mark Isalan
Keywords(s): Biotechnology, Gene Therapy, Genetic Diseases, Neurodegenerative Diseases, Neuromuscular & Movement Disorders, Neuroscience, Rare / Orphan Diseases
Category(s): Biotechnology, General Biology & Chemistry, Therapeutics (Biologics & Compounds)
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Novel peptide sequences for efficient protein secretion in bacteria
The peptides of the invention drive the optimal secretion of fused polypeptides out of Mycoplasma cells.They have multiple potential applications, in particular in the area of synthetic biology and next-generation bacterial-based therapies and vaccination.Technology:Synthetic biology enables researchers to engineer biological systems for a myriad of...
Published: 4/28/2020
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Inventor(s): Luis Serrano, Maria Lluch, Bernhard Paetzold
Keywords(s): Bioengineering, Synthetic Biology
Category(s): Therapeutics (Biologics & Compounds), Biotechnology, Life Stock & Agriculture, Research Tools (cell lines, mice, kits, ABs, ...), Vaccines
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