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Novel RNA Binding Protein Targets to Treat Melanoma
Figure 1. RNA-binding proteins as novel oncological targets. (A) Unbiased screen on cell lines with increasing cancer aggressiveness​. (B) Specific inhibition of the RNA binding domain of one of the hit candidate RBPs affects tumoral cells viability.
Novel antitumoral RNA-binding protein targets in melanoma identified by an unbiased screen.
We are...
Published: 10/28/2024
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Inventor(s): Fatima Gebauer, Neus Mestre Farras, Santiago Guerrero
Keywords(s): Melanoma, Oncology
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
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NudTx: Targeting Cancer Stem Cells
Small molecules hits, and companion diagnostic, selective for the ATP generating activity of NUDT5.
We are developing lead compounds that eventually could be used to complement poly ADP-ribose polymerase therapy or as a treatment on itself as an alternative treatment option to treat primary and metastatic cancers.
Technology:
Recurrence and metastasis...
Published: 10/4/2024
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Inventor(s): Miguel Beato, Roni Wright
Keywords(s): Metastasis, Oncology
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
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Targeting TANGO-1 as a Treatment for Fibrosis (TARTF)
Collagen secretion inhibition in cell and mouse models of fibrosis
Compounds that inhibit the formation of the collagen endoplasmic reticulum (ER)-exit machinery in fibroblasts reducing collagen secretion. They can be used for treating fibrotic diseases by targeting the key, common pathological issue, collagen secretion.
Technology:
Fibrosis underpins...
Published: 11/11/2024
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Inventor(s): Vivek Malhotra, Ishier Raote, Thomas Krieg, Beate Eckes, Ines Neundorf
Keywords(s): Dermatology, Fibrosis, Respiratory Tract Diseases
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
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Novel Therapeutic Targets for DIPG
Various antitumoral targets identified from an unbiased multiomics screen on H3K27M mutated Diffuse Midline Glioma patient-derived material.
We are finalizing target validation and developing high throughput small molecule screening assays to develop novel compounds that can be used to treat this devastating childhood cancer.
Technology:
Diffuse...
Published: 11/21/2024
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Inventor(s): Luciano Di Croce, Maria Espejo Diaz
Keywords(s): Epigenetics, Oncology, Paediatric Disease
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
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New, targeted lung cancer treatment with splicing-modifying antisense oligonucleotides
A lead splicing-modifying antisense oligonucleotide (AON) delivered to different mice models of lung cancer effectively reduces tumor growth in vivo.
The lead AON could be applicable to the targeted treatment of lung adenocarcinoma, lung squamous cell carcinoma, breast, liver, prostate, colon, cervix and other tumor types displaying enhanced NUMB...
Published: 10/10/2024
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Inventor(s): Juan Valcarcel, Jordi Hernandez Ribera, Elias Bechara
Keywords(s): Oncology, RNA Modulation Technologies, Spliceosome / Splicing
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
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